A tin-silver mine working a group of parallel veins up to 60cm wide (rarely 1 m) hosted in sandstone and rhyodacitic tuff. Veins include the Rosario, Carmen, Porvenir, Esperanza, Paniagua and Boyadora.
(This mine hosted the government mining corporation office (COMIBOL) for the whole district, so some old (1970s - early 1980s) vivianite specimens from the nearby Morococala mine were wrongly attributed to the Santa Fé mine since they were acquired from engineers at the COMIBOL office.)